BDBM278929 N-(4- chlorothiophen- 3-yl)-2-[(1S,4S)- or (1R,4R)-2,5- diazabicyclo- [2.2.2]oct-2-yl]- thieno[2,3-b]- pyrazine-7- carboxamide trifluoroacetate::US10040802, Example 109

SMILES OC(=O)C(F)(F)F.Clc1cscc1NC(=O)c1csc2ncc(nc12)N1C[C@H]2CC[C@@H]1CN2

InChI Key InChIKey=HRNVPXJXLLHGQV-DHTOPLTISA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 278929   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM278929(N-(4- chlorothiophen- 3-yl)-2-[(1S,4S)- or (1R,4R)...)
Affinity DataIC50:  104nMpH: 7.2Assay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent