BDBM278985 5-(2-ethoxypyridin-3-yl)-1-methyl-N-(1-(1-methyl-1H-pyrazol-4-yl)ethyl)-1H-pyrazolo[4,3-b]pyridin-7-amine (racemic)::US10034861, Example 15::US10766893, Example S15::US10806718, Example 15::US11026923, Example 15::US11491140, Example 15

SMILES CCOc1ncccc1-c1cc(NC(C)c2cnn(C)c2)c2n(C)ncc2n1

InChI Key InChIKey=PRZKTPKTSVRPRD-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 278985   

LigandPNGBDBM278985(5-(2-ethoxypyridin-3-yl)-1-methyl-N-(1-(1-methyl-1...)
Affinity DataIC50:  820nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278985(5-(2-ethoxypyridin-3-yl)-1-methyl-N-(1-(1-methyl-1...)
Affinity DataIC50:  200nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278985(5-(2-ethoxypyridin-3-yl)-1-methyl-N-(1-(1-methyl-1...)
Affinity DataIC50:  1.00E+4nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278985(5-(2-ethoxypyridin-3-yl)-1-methyl-N-(1-(1-methyl-1...)
Affinity DataIC50:  820nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278985(5-(2-ethoxypyridin-3-yl)-1-methyl-N-(1-(1-methyl-1...)
Affinity DataIC50:  200nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278985(5-(2-ethoxypyridin-3-yl)-1-methyl-N-(1-(1-methyl-1...)
Affinity DataIC50:  36nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278985(5-(2-ethoxypyridin-3-yl)-1-methyl-N-(1-(1-methyl-1...)
Affinity DataIC50:  36nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278985(5-(2-ethoxypyridin-3-yl)-1-methyl-N-(1-(1-methyl-1...)
Affinity DataIC50:  200nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278985(5-(2-ethoxypyridin-3-yl)-1-methyl-N-(1-(1-methyl-1...)
Affinity DataIC50:  820nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278985(5-(2-ethoxypyridin-3-yl)-1-methyl-N-(1-(1-methyl-1...)
Affinity DataIC50:  200nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278985(5-(2-ethoxypyridin-3-yl)-1-methyl-N-(1-(1-methyl-1...)
Affinity DataIC50:  36nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278985(5-(2-ethoxypyridin-3-yl)-1-methyl-N-(1-(1-methyl-1...)
Affinity DataIC50:  820nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278985(5-(2-ethoxypyridin-3-yl)-1-methyl-N-(1-(1-methyl-1...)
Affinity DataIC50:  200nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278985(5-(2-ethoxypyridin-3-yl)-1-methyl-N-(1-(1-methyl-1...)
Affinity DataIC50:  820nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent