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BDBM278985 5-(2-ethoxypyridin-3-yl)-1-methyl-N-(1-(1-methyl-1H-pyrazol-4-yl)ethyl)-1H-pyrazolo[4,3-b]pyridin-7-amine (racemic)::US10034861, Example 15

SMILES: CCOc1ncccc1-c1cc(NC(C)c2cnn(C)c2)c2n(C)ncc2n1

InChI Key: InChIKey=PRZKTPKTSVRPRD-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 278985   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 1A (PDE1A)


(Homo sapiens (Human))
BDBM278985
PNG
(5-(2-ethoxypyridin-3-yl)-1-methyl-N-(1-(1-methyl-1...)
Show SMILES CCOc1ncccc1-c1cc(NC(C)c2cnn(C)c2)c2n(C)ncc2n1
Show InChI InChI=1S/C20H23N7O/c1-5-28-20-15(7-6-8-21-20)16-9-17(19-18(25-16)11-23-27(19)4)24-13(2)14-10-22-26(3)12-14/h6-13H,5H2,1-4H3,(H,24,25)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 820n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase 1C (PDE1C)


(Homo sapiens (Human))
BDBM278985
PNG
(5-(2-ethoxypyridin-3-yl)-1-methyl-N-(1-(1-methyl-1...)
Show SMILES CCOc1ncccc1-c1cc(NC(C)c2cnn(C)c2)c2n(C)ncc2n1
Show InChI InChI=1S/C20H23N7O/c1-5-28-20-15(7-6-8-21-20)16-9-17(19-18(25-16)11-23-27(19)4)24-13(2)14-10-22-26(3)12-14/h6-13H,5H2,1-4H3,(H,24,25)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.00E+4n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM278985
PNG
(5-(2-ethoxypyridin-3-yl)-1-methyl-N-(1-(1-methyl-1...)
Show SMILES CCOc1ncccc1-c1cc(NC(C)c2cnn(C)c2)c2n(C)ncc2n1
Show InChI InChI=1S/C20H23N7O/c1-5-28-20-15(7-6-8-21-20)16-9-17(19-18(25-16)11-23-27(19)4)24-13(2)14-10-22-26(3)12-14/h6-13H,5H2,1-4H3,(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 200n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair