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BDBM278986 5-(2-ethoxypyridin-3-yl)-1-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 16

SMILES: CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(C)ncc2n1

InChI Key: InChIKey=IHPVHEUBCHVJEQ-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 278986   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 1A (PDE1A)


(Homo sapiens (Human))
BDBM278986
PNG
(5-(2-ethoxypyridin-3-yl)-1-methyl-N-((1-methyl-1H-...)
Show SMILES CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(C)ncc2n1
Show InChI InChI=1S/C19H21N7O/c1-4-27-19-14(6-5-7-20-19)15-8-16(18-17(24-15)11-23-26(18)3)21-9-13-10-22-25(2)12-13/h5-8,10-12H,4,9H2,1-3H3,(H,21,24)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 670n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase 1C (PDE1C)


(Homo sapiens (Human))
BDBM278986
PNG
(5-(2-ethoxypyridin-3-yl)-1-methyl-N-((1-methyl-1H-...)
Show SMILES CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(C)ncc2n1
Show InChI InChI=1S/C19H21N7O/c1-4-27-19-14(6-5-7-20-19)15-8-16(18-17(24-15)11-23-26(18)3)21-9-13-10-22-25(2)12-13/h5-8,10-12H,4,9H2,1-3H3,(H,21,24)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.80E+3n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM278986
PNG
(5-(2-ethoxypyridin-3-yl)-1-methyl-N-((1-methyl-1H-...)
Show SMILES CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(C)ncc2n1
Show InChI InChI=1S/C19H21N7O/c1-4-27-19-14(6-5-7-20-19)15-8-16(18-17(24-15)11-23-26(18)3)21-9-13-10-22-25(2)12-13/h5-8,10-12H,4,9H2,1-3H3,(H,21,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 92n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair