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BDBM278996 5-(2-ethoxy-3-pyridyl)-1-ethyl-N-[(1-methylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 26

SMILES: CCOc1ccncc1-c1cc(NCc2cnn(C)c2)c2n(CC)ncc2n1

InChI Key: InChIKey=OKGINEWBFLWKOX-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 278996   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 1A (PDE1A)


(Homo sapiens (Human))
BDBM278996
PNG
(5-(2-ethoxy-3-pyridyl)-1-ethyl-N-[(1-methylpyrazol...)
Show SMILES CCOc1ccncc1-c1cc(NCc2cnn(C)c2)c2n(CC)ncc2n1
Show InChI InChI=1S/C20H23N7O/c1-4-27-20-17(22-9-14-10-23-26(3)13-14)8-16(25-18(20)12-24-27)15-11-21-7-6-19(15)28-5-2/h6-8,10-13H,4-5,9H2,1-3H3,(H,22,25)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 140n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase 1C (PDE1C)


(Homo sapiens (Human))
BDBM278996
PNG
(5-(2-ethoxy-3-pyridyl)-1-ethyl-N-[(1-methylpyrazol...)
Show SMILES CCOc1ccncc1-c1cc(NCc2cnn(C)c2)c2n(CC)ncc2n1
Show InChI InChI=1S/C20H23N7O/c1-4-27-20-17(22-9-14-10-23-26(3)13-14)8-16(25-18(20)12-24-27)15-11-21-7-6-19(15)28-5-2/h6-8,10-13H,4-5,9H2,1-3H3,(H,22,25)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 440n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM278996
PNG
(5-(2-ethoxy-3-pyridyl)-1-ethyl-N-[(1-methylpyrazol...)
Show SMILES CCOc1ccncc1-c1cc(NCc2cnn(C)c2)c2n(CC)ncc2n1
Show InChI InChI=1S/C20H23N7O/c1-4-27-20-17(22-9-14-10-23-26(3)13-14)8-16(25-18(20)12-24-27)15-11-21-7-6-19(15)28-5-2/h6-8,10-13H,4-5,9H2,1-3H3,(H,22,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 22n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair