BindingDB logo
myBDB logout

BDBM279009 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 39

SMILES: CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)C

InChI Key: InChIKey=UOWVOVPKNPTQQH-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 279009   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 1A (PDE1A)


(Homo sapiens (Human))
BDBM279009
PNG
(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-...)
Show SMILES CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)C
Show InChI InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-9-22-21)17-11-18(23-12-15-8-10-24-26-15)20-19(25-17)14(4)27-28(20)13(2)3/h6-11,13H,5,12H2,1-4H3,(H,23,25)(H,24,26)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8.10n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase 1C (PDE1C)


(Homo sapiens (Human))
BDBM279009
PNG
(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-...)
Show SMILES CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)C
Show InChI InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-9-22-21)17-11-18(23-12-15-8-10-24-26-15)20-19(25-17)14(4)27-28(20)13(2)3/h6-11,13H,5,12H2,1-4H3,(H,23,25)(H,24,26)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 13n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (Human))
BDBM279009
PNG
(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-...)
Show SMILES CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)C
Show InChI InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-9-22-21)17-11-18(23-12-15-8-10-24-26-15)20-19(25-17)14(4)27-28(20)13(2)3/h6-11,13H,5,12H2,1-4H3,(H,23,25)(H,24,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.430n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair