BDBM279015 3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4-yl)methyl)amino)-1H-pyrazolo[4,3-b]pyridin-5-yl)-1-methylpyridin-2(1H)-one::US10034861, Example 45::US10512632, Example 45::US10806718, Example 45::US11026923, Example 45::US11491140, Example 45::US11634416, Example 45

SMILES CCOc1ncccc1-c1cc(NCc2ccc(=O)n(C)c2)c2n(nc(C)c2n1)C(C)C

InChI Key InChIKey=IFSZKCSGKSFXTM-UHFFFAOYSA-N

Data  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 279015   

LigandPNGBDBM279015(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Affinity DataIC50:  8nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279015(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Affinity DataIC50:  16nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279015(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Affinity DataIC50:  16nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279015(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Affinity DataIC50:  8nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279015(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Affinity DataIC50:  0.620nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279015(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Affinity DataIC50:  16nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279015(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Affinity DataIC50:  8nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279015(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Affinity DataIC50:  0.620nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279015(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Affinity DataIC50:  16nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279015(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Affinity DataIC50:  8nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279015(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Affinity DataIC50:  0.620nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279015(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Affinity DataIC50:  16nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279015(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Affinity DataIC50:  8nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279015(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Affinity DataIC50:  0.620nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279015(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Affinity DataIC50:  16nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279015(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Affinity DataIC50:  8nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279015(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Affinity DataIC50:  0.620nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279015(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Affinity DataIC50:  0.620nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent