BDBM279019 3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4-yl)methyl)amino)-1H-pyrazolo[4,3-b]pyridin-5-yl)-1-methylpyridin-2(1H)-one::US10034861, Example 49::US10512632, Example 49::US10766893, Example S49::US10806718, Example 49::US11026923, Example 49::US11491140, Example 49::US11634416, Example 49

SMILES CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cccn(C)c1=O

InChI Key InChIKey=MRQVRXHGMURIIP-UHFFFAOYSA-N

Data  24 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 279019   

LigandPNGBDBM279019(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Affinity DataIC50:  170nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279019(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Affinity DataIC50:  420nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279019(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Affinity DataIC50:  420nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279019(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Affinity DataIC50:  170nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279019(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Affinity DataIC50:  20nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279019(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Affinity DataIC50:  420nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279019(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Affinity DataIC50:  8nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279019(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Affinity DataIC50:  0.620nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279019(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Affinity DataIC50:  16nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279019(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Affinity DataIC50:  170nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279019(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Affinity DataIC50:  20nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279019(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Affinity DataIC50:  420nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279019(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Affinity DataIC50:  170nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279019(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Affinity DataIC50:  20nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279019(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Affinity DataIC50:  420nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279019(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Affinity DataIC50:  170nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279019(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Affinity DataIC50:  20nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279019(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Affinity DataIC50:  420nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279019(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Affinity DataIC50:  170nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279019(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Affinity DataIC50:  20nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279019(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Affinity DataIC50:  420nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279019(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Affinity DataIC50:  170nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279019(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Affinity DataIC50:  20nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279019(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Affinity DataIC50:  20nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent