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BDBM279065 1-isopropyl-5-(2-methoxy-3-pyridyl)-N-[(6-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 96

SMILES: COc1ccc(CNc2cc(nc3c(C)nn(C(C)C)c23)-c2cccnc2OC)cn1

InChI Key: InChIKey=HUQJJAUBVULGLS-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 279065   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 1A (PDE1A)


(Homo sapiens (Human))
BDBM279065
PNG
(1-isopropyl-5-(2-methoxy-3-pyridyl)-N-[(6-methoxy-...)
Show SMILES COc1ccc(CNc2cc(nc3c(C)nn(C(C)C)c23)-c2cccnc2OC)cn1
Show InChI InChI=1S/C23H26N6O2/c1-14(2)29-22-19(25-12-16-8-9-20(30-4)26-13-16)11-18(27-21(22)15(3)28-29)17-7-6-10-24-23(17)31-5/h6-11,13-14H,12H2,1-5H3,(H,25,27)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 18n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase 1C (PDE1C)


(Homo sapiens (Human))
BDBM279065
PNG
(1-isopropyl-5-(2-methoxy-3-pyridyl)-N-[(6-methoxy-...)
Show SMILES COc1ccc(CNc2cc(nc3c(C)nn(C(C)C)c23)-c2cccnc2OC)cn1
Show InChI InChI=1S/C23H26N6O2/c1-14(2)29-22-19(25-12-16-8-9-20(30-4)26-13-16)11-18(27-21(22)15(3)28-29)17-7-6-10-24-23(17)31-5/h6-11,13-14H,12H2,1-5H3,(H,25,27)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.30n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (Human))
BDBM279065
PNG
(1-isopropyl-5-(2-methoxy-3-pyridyl)-N-[(6-methoxy-...)
Show SMILES COc1ccc(CNc2cc(nc3c(C)nn(C(C)C)c23)-c2cccnc2OC)cn1
Show InChI InChI=1S/C23H26N6O2/c1-14(2)29-22-19(25-12-16-8-9-20(30-4)26-13-16)11-18(27-21(22)15(3)28-29)17-7-6-10-24-23(17)31-5/h6-11,13-14H,12H2,1-5H3,(H,25,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.80n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair