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BDBM279068 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(2H-tetrazol-5-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 99

SMILES: CCOc1ncccc1-c1cc(NCc2nn[nH]n2)c2n(nc(C)c2n1)C(C)C

InChI Key: InChIKey=DBRGOFPEANLZGU-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 279068   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 1A (PDE1A)


(Homo sapiens (Human))
BDBM279068
PNG
(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(2H-...)
Show SMILES CCOc1ncccc1-c1cc(NCc2nn[nH]n2)c2n(nc(C)c2n1)C(C)C
Show InChI InChI=1S/C19H23N9O/c1-5-29-19-13(7-6-8-20-19)14-9-15(21-10-16-23-26-27-24-16)18-17(22-14)12(4)25-28(18)11(2)3/h6-9,11H,5,10H2,1-4H3,(H,21,22)(H,23,24,26,27)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.730n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase 1C (PDE1C)


(Homo sapiens (Human))
BDBM279068
PNG
(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(2H-...)
Show SMILES CCOc1ncccc1-c1cc(NCc2nn[nH]n2)c2n(nc(C)c2n1)C(C)C
Show InChI InChI=1S/C19H23N9O/c1-5-29-19-13(7-6-8-20-19)14-9-15(21-10-16-23-26-27-24-16)18-17(22-14)12(4)25-28(18)11(2)3/h6-9,11H,5,10H2,1-4H3,(H,21,22)(H,23,24,26,27)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.80n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (Human))
BDBM279068
PNG
(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(2H-...)
Show SMILES CCOc1ncccc1-c1cc(NCc2nn[nH]n2)c2n(nc(C)c2n1)C(C)C
Show InChI InChI=1S/C19H23N9O/c1-5-29-19-13(7-6-8-20-19)14-9-15(21-10-16-23-26-27-24-16)18-17(22-14)12(4)25-28(18)11(2)3/h6-9,11H,5,10H2,1-4H3,(H,21,22)(H,23,24,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.310n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair