BDBM279075 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 106::US10512632, Example 106::US10766893, Example S106::US10806718, Example 106::US11026923, Example 106::US11491140, Example 106::US11634416, Example 106

SMILES CCOc1ncccc1-c1cc(NCc2cncc(OC)c2)c2n(nc(C)c2n1)C(C)C

InChI Key InChIKey=JCOKQWFPIMEUNS-UHFFFAOYSA-N

Data  21 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 279075   

LigandPNGBDBM279075(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxy-3...)
Affinity DataIC50:  2.10nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279075(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxy-3...)
Affinity DataIC50:  3.90nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279075(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxy-3...)
Affinity DataIC50:  3.90nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279075(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxy-3...)
Affinity DataIC50:  2.10nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279075(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxy-3...)
Affinity DataIC50:  0.450nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279075(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxy-3...)
Affinity DataIC50:  3.90nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279075(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxy-3...)
Affinity DataIC50:  2.10nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279075(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxy-3...)
Affinity DataIC50:  0.450nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279075(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxy-3...)
Affinity DataIC50:  3.90nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279075(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxy-3...)
Affinity DataIC50:  2.10nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279075(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxy-3...)
Affinity DataIC50:  0.450nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279075(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxy-3...)
Affinity DataIC50:  3.90nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279075(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxy-3...)
Affinity DataIC50:  2.10nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279075(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxy-3...)
Affinity DataIC50:  0.450nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279075(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxy-3...)
Affinity DataIC50:  3.90nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279075(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxy-3...)
Affinity DataIC50:  2.10nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279075(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxy-3...)
Affinity DataIC50:  0.450nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279075(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxy-3...)
Affinity DataIC50:  3.90nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279075(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxy-3...)
Affinity DataIC50:  2.10nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279075(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxy-3...)
Affinity DataIC50:  0.450nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279075(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methoxy-3...)
Affinity DataIC50:  0.450nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent