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BDBM279079 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(1-propylpyrazol-4-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 110

SMILES: CCCn1cc(CNc2cc(nc3c(C)nn(C(C)C)c23)-c2cccnc2OCC)cn1

InChI Key: InChIKey=NPLKFZSTTQLUHS-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 279079   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 1A (PDE1A)


(Homo sapiens (Human))
BDBM279079
PNG
(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(1-...)
Show SMILES CCCn1cc(CNc2cc(nc3c(C)nn(C(C)C)c23)-c2cccnc2OCC)cn1
Show InChI InChI=1S/C24H31N7O/c1-6-11-30-15-18(14-27-30)13-26-21-12-20(19-9-8-10-25-24(19)32-7-2)28-22-17(5)29-31(16(3)4)23(21)22/h8-10,12,14-16H,6-7,11,13H2,1-5H3,(H,26,28)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 11n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase 1C (PDE1C)


(Homo sapiens (Human))
BDBM279079
PNG
(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(1-...)
Show SMILES CCCn1cc(CNc2cc(nc3c(C)nn(C(C)C)c23)-c2cccnc2OCC)cn1
Show InChI InChI=1S/C24H31N7O/c1-6-11-30-15-18(14-27-30)13-26-21-12-20(19-9-8-10-25-24(19)32-7-2)28-22-17(5)29-31(16(3)4)23(21)22/h8-10,12,14-16H,6-7,11,13H2,1-5H3,(H,26,28)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8.5n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (Human))
BDBM279079
PNG
(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(1-...)
Show SMILES CCCn1cc(CNc2cc(nc3c(C)nn(C(C)C)c23)-c2cccnc2OCC)cn1
Show InChI InChI=1S/C24H31N7O/c1-6-11-30-15-18(14-27-30)13-26-21-12-20(19-9-8-10-25-24(19)32-7-2)28-22-17(5)29-31(16(3)4)23(21)22/h8-10,12,14-16H,6-7,11,13H2,1-5H3,(H,26,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.10n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair