BDBM279101 5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methylimidazol-4-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 132
SMILES: CCOc1ncccc1-c1cc(NCc2cn(C)cn2)c2n(nc(C)c2n1)C(C)CC
InChI Key: InChIKey=NIXYLBKMUOTNON-UHFFFAOYNA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphodiesterase 1A (PDE1A) (Homo sapiens (Human)) | BDBM279101![]() (5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methylimidaz...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 0.140 | n/a | n/a | n/a | n/a | 7.6 | 25 |
H. Lundbeck A/S US Patent | Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ... | US Patent US10034861 (2018) Article DOI: 10.1021/jm9804681 BindingDB Entry DOI: 10.7270/Q2X350HN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase 1C (PDE1C) (Homo sapiens (Human)) | BDBM279101![]() (5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methylimidaz...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 0.520 | n/a | n/a | n/a | n/a | 7.6 | 25 |
H. Lundbeck A/S US Patent | Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ... | US Patent US10034861 (2018) Article DOI: 10.1021/jm9804681 BindingDB Entry DOI: 10.7270/Q2X350HN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase, PDE1/PDE5 (Homo sapiens (Human)) | BDBM279101![]() (5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methylimidaz...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem | Article US Patent | n/a | n/a | 0.0450 | n/a | n/a | n/a | n/a | 7.6 | 25 |
H. Lundbeck A/S US Patent | Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ... | US Patent US10034861 (2018) Article DOI: 10.1021/jm9804681 BindingDB Entry DOI: 10.7270/Q2X350HN | |||||||||||
More data for this Ligand-Target Pair |