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BDBM279120 3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]oxazolidin-2-one::US10034861, Example 151

SMILES: CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1CCOC1=O

InChI Key: InChIKey=CBOOBJUJEUVRPS-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 279120   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 1A (PDE1A)


(Homo sapiens (Human))
BDBM279120
PNG
(3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)m...)
Show SMILES CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1CCOC1=O
Show InChI InChI=1S/C18H23N7O2/c1-11(2)25-17-14(19-8-13-9-20-23(4)10-13)7-15(21-16(17)12(3)22-25)24-5-6-27-18(24)26/h7,9-11H,5-6,8H2,1-4H3,(H,19,21)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase 1C (PDE1C)


(Homo sapiens (Human))
BDBM279120
PNG
(3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)m...)
Show SMILES CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1CCOC1=O
Show InChI InChI=1S/C18H23N7O2/c1-11(2)25-17-14(19-8-13-9-20-23(4)10-13)7-15(21-16(17)12(3)22-25)24-5-6-27-18(24)26/h7,9-11H,5-6,8H2,1-4H3,(H,19,21)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 12n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (Human))
BDBM279120
PNG
(3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)m...)
Show SMILES CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)N1CCOC1=O
Show InChI InChI=1S/C18H23N7O2/c1-11(2)25-17-14(19-8-13-9-20-23(4)10-13)7-15(21-16(17)12(3)22-25)24-5-6-27-18(24)26/h7,9-11H,5-6,8H2,1-4H3,(H,19,21)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.70n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair