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BDBM279125 4-ethyl-3-[1-isopropyl-3-methyl-7-[(1-methylpyrazol-4-yl)methylamino]pyrazolo[4,3-b]pyridin-5-yl]oxazolidin-2-one::US10034861, Example 156

SMILES: CCC1COC(=O)N1c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C

InChI Key: InChIKey=CVOILQIVJFYVAQ-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 279125   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 1A (PDE1A)


(Homo sapiens (Human))
BDBM279125
PNG
(4-ethyl-3-[1-isopropyl-3-methyl-7-[(1-methylpyrazo...)
Show SMILES CCC1COC(=O)N1c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C
Show InChI InChI=1S/C20H27N7O2/c1-6-15-11-29-20(28)26(15)17-7-16(21-8-14-9-22-25(5)10-14)19-18(23-17)13(4)24-27(19)12(2)3/h7,9-10,12,15H,6,8,11H2,1-5H3,(H,21,23)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 31n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase 1C (PDE1C)


(Homo sapiens (Human))
BDBM279125
PNG
(4-ethyl-3-[1-isopropyl-3-methyl-7-[(1-methylpyrazo...)
Show SMILES CCC1COC(=O)N1c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C
Show InChI InChI=1S/C20H27N7O2/c1-6-15-11-29-20(28)26(15)17-7-16(21-8-14-9-22-25(5)10-14)19-18(23-17)13(4)24-27(19)12(2)3/h7,9-10,12,15H,6,8,11H2,1-5H3,(H,21,23)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.10n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM279125
PNG
(4-ethyl-3-[1-isopropyl-3-methyl-7-[(1-methylpyrazo...)
Show SMILES CCC1COC(=O)N1c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C
Show InChI InChI=1S/C20H27N7O2/c1-6-15-11-29-20(28)26(15)17-7-16(21-8-14-9-22-25(5)10-14)19-18(23-17)13(4)24-27(19)12(2)3/h7,9-10,12,15H,6,8,11H2,1-5H3,(H,21,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 31n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair