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BDBM279166 5-(2-ethoxy-3-pyridyl)-N-[(2-methoxy-3-pyridyl)methyl]-3-methyl-1-(oxetan-3-yl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 197

SMILES: CCOc1ncccc1-c1cc(NCc2cccnc2OC)c2n(nc(C)c2n1)C1COC1

InChI Key: InChIKey=GRFJYHDUOKDAKO-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 279166   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 1A (PDE1A)


(Homo sapiens (Human))
BDBM279166
PNG
(5-(2-ethoxy-3-pyridyl)-N-[(2-methoxy-3-pyridyl)met...)
Show SMILES CCOc1ncccc1-c1cc(NCc2cccnc2OC)c2n(nc(C)c2n1)C1COC1
Show InChI InChI=1S/C24H26N6O3/c1-4-33-24-18(8-6-10-26-24)19-11-20(27-12-16-7-5-9-25-23(16)31-3)22-21(28-19)15(2)29-30(22)17-13-32-14-17/h5-11,17H,4,12-14H2,1-3H3,(H,27,28)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 190n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase 1C (PDE1C)


(Homo sapiens (Human))
BDBM279166
PNG
(5-(2-ethoxy-3-pyridyl)-N-[(2-methoxy-3-pyridyl)met...)
Show SMILES CCOc1ncccc1-c1cc(NCc2cccnc2OC)c2n(nc(C)c2n1)C1COC1
Show InChI InChI=1S/C24H26N6O3/c1-4-33-24-18(8-6-10-26-24)19-11-20(27-12-16-7-5-9-25-23(16)31-3)22-21(28-19)15(2)29-30(22)17-13-32-14-17/h5-11,17H,4,12-14H2,1-3H3,(H,27,28)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 190n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM279166
PNG
(5-(2-ethoxy-3-pyridyl)-N-[(2-methoxy-3-pyridyl)met...)
Show SMILES CCOc1ncccc1-c1cc(NCc2cccnc2OC)c2n(nc(C)c2n1)C1COC1
Show InChI InChI=1S/C24H26N6O3/c1-4-33-24-18(8-6-10-26-24)19-11-20(27-12-16-7-5-9-25-23(16)31-3)22-21(28-19)15(2)29-30(22)17-13-32-14-17/h5-11,17H,4,12-14H2,1-3H3,(H,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 13n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair