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BDBM280104 US10028961, Compound 257

SMILES: FC(F)(F)c1cccc(n1)-c1nc(NC2CC3(C2)CC(F)(F)C3)nc(Nc2ccnc(c2)C(F)(F)F)n1

InChI Key: InChIKey=BTPLBROFKCBOEI-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 280104   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
IDH1 R132H


(Homo sapiens (human))
BDBM280104
PNG
(US10028961, Compound 257)
Show SMILES FC(F)(F)c1cccc(n1)-c1nc(NC2CC3(C2)CC(F)(F)C3)nc(Nc2ccnc(c2)C(F)(F)F)n1
Show InChI InChI=1S/C22H17F8N7/c23-20(24)9-19(10-20)7-12(8-19)33-18-36-16(13-2-1-3-14(34-13)21(25,26)27)35-17(37-18)32-11-4-5-31-15(6-11)22(28,29)30/h1-6,12H,7-10H2,(H2,31,32,33,35,36,37)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/a7.525



Agios Pharmaceuticals, Inc.

US Patent


Assay Description
A test compound is prepared as 10 mM stock in DMSO and diluted to 50 final concentration in DMSO, for a 50 μl reaction mixture. IDH enzyme acti...


US Patent US10028961 (2018)

More data for this
Ligand-Target Pair
IDH2(R140Q)


(Homo sapiens (Human))
BDBM280104
PNG
(US10028961, Compound 257)
Show SMILES FC(F)(F)c1cccc(n1)-c1nc(NC2CC3(C2)CC(F)(F)C3)nc(Nc2ccnc(c2)C(F)(F)F)n1
Show InChI InChI=1S/C22H17F8N7/c23-20(24)9-19(10-20)7-12(8-19)33-18-36-16(13-2-1-3-14(34-13)21(25,26)27)35-17(37-18)32-11-4-5-31-15(6-11)22(28,29)30/h1-6,12H,7-10H2,(H2,31,32,33,35,36,37)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/a7.525



Agios Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...


US Patent US10028961 (2018)

More data for this
Ligand-Target Pair
IDH1 R132C


(Homo sapiens (human))
BDBM280104
PNG
(US10028961, Compound 257)
Show SMILES FC(F)(F)c1cccc(n1)-c1nc(NC2CC3(C2)CC(F)(F)C3)nc(Nc2ccnc(c2)C(F)(F)F)n1
Show InChI InChI=1S/C22H17F8N7/c23-20(24)9-19(10-20)7-12(8-19)33-18-36-16(13-2-1-3-14(34-13)21(25,26)27)35-17(37-18)32-11-4-5-31-15(6-11)22(28,29)30/h1-6,12H,7-10H2,(H2,31,32,33,35,36,37)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/a6.525



Agios Pharmaceuticals, Inc.

US Patent


Assay Description
In the primary reaction, the reduction of α-KG acid to 2-HG is accompanied by a concomitant oxidation of NADPH to NADP. The amount of NADPH rema...


US Patent US10028961 (2018)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM280104
PNG
(US10028961, Compound 257)
Show SMILES FC(F)(F)c1cccc(n1)-c1nc(NC2CC3(C2)CC(F)(F)C3)nc(Nc2ccnc(c2)C(F)(F)F)n1
Show InChI InChI=1S/C22H17F8N7/c23-20(24)9-19(10-20)7-12(8-19)33-18-36-16(13-2-1-3-14(34-13)21(25,26)27)35-17(37-18)32-11-4-5-31-15(6-11)22(28,29)30/h1-6,12H,7-10H2,(H2,31,32,33,35,36,37)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/a6.525



Agios Pharmaceuticals, Inc.

US Patent


Assay Description
In the primary reaction, the reduction of α-KG acid to 2-HG is accompanied by a concomitant oxidation of NADPH to NADP. The amount of NADPH rema...


US Patent US10028961 (2018)

More data for this
Ligand-Target Pair