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BDBM281597 US10022461, Compound 44

SMILES: Fc1cc(ccn1)-c1ccc(nc1)-n1ccc2ccncc12

InChI Key: InChIKey=SESSNUBLMUDAHR-UHFFFAOYSA-N

Data: 1 KI

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 281597   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281597
PNG
(US10022461, Compound 44)
Show SMILES Fc1cc(ccn1)-c1ccc(nc1)-n1ccc2ccncc12
Show InChI InChI=1S/C17H11FN4/c18-16-9-13(4-7-20-16)14-1-2-17(21-10-14)22-8-5-12-3-6-19-11-15(12)22/h1-11H
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
1.13 -12.2n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair