BindingDB logo
myBDB logout

BDBM281606 US10022461, Compound 56

SMILES: Oc1cccc2cc(ncc12)-n1ccc2ccncc12

InChI Key: InChIKey=AYXRYOIPOKGSSK-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 281606   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281606
PNG
(US10022461, Compound 56)
Show SMILES Oc1cccc2cc(ncc12)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11N3O/c20-15-3-1-2-12-8-16(18-9-13(12)15)19-7-5-11-4-6-17-10-14(11)19/h1-10,20H
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
UniChem
1.16n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair