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BDBM281622 US10022461, Compound 72

SMILES: CNc1cccc(c1)-c1ccc(nc1)-n1ccc2ccncc12

InChI Key: InChIKey=UJVPNGCHONKGFS-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 281622   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281622
PNG
(US10022461, Compound 72)
Show SMILES CNc1cccc(c1)-c1ccc(nc1)-n1ccc2ccncc12
Show InChI InChI=1S/C19H16N4/c1-20-17-4-2-3-15(11-17)16-5-6-19(22-12-16)23-10-8-14-7-9-21-13-18(14)23/h2-13,20H,1H3
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
UniChem
0.760n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair