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BDBM281624 US10022461, Compound 88

SMILES: CNc1ccc(cn1)-c1ccc(nc1)-n1ccc2ccncc12

InChI Key: InChIKey=CCHHSGJIZPTCHZ-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 281624   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281624
PNG
(US10022461, Compound 88)
Show SMILES CNc1ccc(cn1)-c1ccc(nc1)-n1ccc2ccncc12
Show InChI InChI=1S/C18H15N5/c1-19-17-4-2-14(10-21-17)15-3-5-18(22-11-15)23-9-7-13-6-8-20-12-16(13)23/h2-12H,1H3,(H,19,21)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
0.690 -12.5n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair