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BDBM281628 US10022461, Compound 95

SMILES: CN(C)c1ccc(cn1)-c1ccc(nc1)-n1ccc2ccncc12

InChI Key: InChIKey=QFUJITMJJQZTBU-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 281628   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281628
PNG
(US10022461, Compound 95)
Show SMILES CN(C)c1ccc(cn1)-c1ccc(nc1)-n1ccc2ccncc12
Show InChI InChI=1S/C19H17N5/c1-23(2)18-5-3-15(11-21-18)16-4-6-19(22-12-16)24-10-8-14-7-9-20-13-17(14)24/h3-13H,1-2H3
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
0.960 -12.3n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair