BDBM281739 US10023528, Example 25::US10259776, Example 25

SMILES COC(C)(C)C(CC(O)=O)c1ccc(Cl)c(NC(=O)[C@@H]([C@@H](C)C(F)(F)F)c2ccc(Cl)cc2)c1

InChI Key InChIKey=SYOVPNRDQAHFAQ-KVCBOLPTSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 281739   

TargetGuanylate cyclase soluble subunit alpha-1(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM281739(US10023528, Example 25 | US10259776, Example 25)
Affinity DataEC50:  220nMAssay Description:Soluble guanylate cyclase (sGC) converts on stimulation GTP into cGMP and pyrophosphate (PPi). PPi is detected with the aid of the assay described be...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGuanylate cyclase soluble subunit alpha-1(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM281739(US10023528, Example 25 | US10259776, Example 25)
Affinity DataEC50:  220nMpH: 7.5 T: 2°CAssay Description:To carry out the assay, 29 μl of enzyme solution [0-10 nM soluble guanylate cyclase (prepared according to Hönicka et al, J. Mol. Med. 77, 14-23...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent