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BDBM281802 N-(1-(3,4-difluorophenyl)ethyl)- 2-(((5-(1-methyl-1H-imidazo[4,5-c] quinolin-8-yl)thiophen-2-yl)methyl) amino)nicotinamide::US10030016, Example 2.24

SMILES: Cn1cnc2cnc3ccc(cc3c12)-c1ccc(CNc2ncccc2C(=O)NCc2ccc(F)c(F)c2)s1

InChI Key: InChIKey=ZLARKOCDKIRYTA-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 281802   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM281802
PNG
(N-(1-(3,4-difluorophenyl)ethyl)- 2-(((5-(1-methyl-...)
Show SMILES Cn1cnc2cnc3ccc(cc3c12)-c1ccc(CNc2ncccc2C(=O)NCc2ccc(F)c(F)c2)s1
Show InChI InChI=1S/C29H22F2N6OS/c1-37-16-36-25-15-33-24-8-5-18(12-21(24)27(25)37)26-9-6-19(39-26)14-34-28-20(3-2-10-32-28)29(38)35-13-17-4-7-22(30)23(31)11-17/h2-12,15-16H,13-14H2,1H3,(H,32,34)(H,35,38)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair