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BDBM281810 2-(((5-(1H-pyrazolo[3,4-b]pyridin- 5-yl)thiophen-2-yl)methyl)amino)- N-(3,4-difluorobenzyl) nicotinamide::US10030016, Example 2.32

SMILES: Fc1ccc(CNC(=O)c2cccnc2NCc2ccc(s2)-c2cnc3[nH]ncc3c2)cc1F

InChI Key:

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 281810   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM281810
PNG
(2-(((5-(1H-pyrazolo[3,4-b]pyridin- 5-yl)thiophen-2...)
Show SMILES Fc1ccc(CNC(=O)c2cccnc2NCc2ccc(s2)-c2cnc3[nH]ncc3c2)cc1F
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair