BDBM282386 (S)-2-(4-(3-amino-1H-pyrazolo [3,4-b]pyridin-5-yl) benzylamino)-N-1-(4- fluorophenyl)-2-hydroxyethyl)- 5-(trifluoromethyl) nicotinamide::US10030016, Example 266

SMILES Nc1n[nH]c2ncc(cc12)-c1ccc(CNc2ncc(cc2C(=O)N[C@H](CO)c2ccc(F)cc2)C(F)(F)F)cc1

InChI Key

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 282386   

Target3-phosphoinositide-dependent protein kinase 1 [51-359](Homo sapiens (Human))
Sunesis Pharmaceuticals

US Patent
LigandPNGBDBM282386((S)-2-(4-(3-amino-1H-pyrazolo [3,4-b]pyridin-5-yl)...)
Affinity DataIC50:  550nMAssay Description:PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent