BDBM282583 US9884843, Compound 10
SMILES OC1c2c(ccc(Oc3cc(F)cc(Cl)c3)c2C#N)S(=O)(=O)C1(F)F
InChI Key InChIKey=JDUPIUFRVRIPBS-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 282583
Affinity DataIC50: 45nMpH: 7.5Assay Description:The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...More data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Homo sapiens (Human))
Peloton Therapeutics
Curated by ChEMBL
Peloton Therapeutics
Curated by ChEMBL
Affinity DataEC50: 9.20E+3nMAssay Description:Antagonist activity at HIF-2alpha in human 786-O cells co-expressing HIF responsive element after 24 hrs by ONE-Glo luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Homo sapiens (Human))
Peloton Therapeutics
Curated by ChEMBL
Peloton Therapeutics
Curated by ChEMBL
Affinity DataIC50: 49nMAssay Description:Binding affinity to His-tagged HIF-2alpha PAS-B domain (unknown origin) after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair