BDBM283190 Rac-N-[1-{N′-cyano-N-[2-(pyrrolidin-1-ylmethyl)-5-(trifluoromethyl)phenyl]carbamimidoy}-3-(3,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol-4-yl]-N-ethyl-2-hydroxyacetamide::US10023539, Example 27

SMILES CCN(C1CN(N=C1c1ccc(Cl)c(Cl)c1)C(\Nc1cc(ccc1CN1CCCC1)C(F)(F)F)=N/C#N)C(=O)CO

InChI Key InChIKey=QSOXOTHDXTVRCQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 283190   

TargetN-lysine methyltransferase SMYD2(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM283190(Rac-N-[1-{N′-cyano-N-[2-(pyrrolidin-1-ylmeth...)
Affinity DataIC50:  95.9nMAssay Description:For the detection of SMYD2 cellular methylation activity an In Cell Western (ICW) assay was established. This assay allows rapid processing of multip...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetN-lysine methyltransferase SMYD2(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM283190(Rac-N-[1-{N′-cyano-N-[2-(pyrrolidin-1-ylmeth...)
Affinity DataIC50:  355nMpH: 9.0Assay Description:SMYD2 inhibitory activities of the compounds described in the present invention were quantified using a scintillation proximity assay (SPA) which mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent