BDBM28365 CHEMBL512355::N-[4-(2-cyanoethyl)cyclohexyl]-N-cyclopropyl-4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzamide::cyclohexyl benzamide derivative, 4

SMILES C[C@](O)(c1ccc(cc1)C(=O)N(C1CC1)[C@H]1CC[C@H](CCC#N)CC1)C(F)(F)F

InChI Key InChIKey=IHSUMNRQVFTRRP-XERREHJYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 28365   

Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen

LigandPNGBDBM28365(CHEMBL512355 | N-[4-(2-cyanoethyl)cyclohexyl]-N-cy...)
Affinity DataIC50:  0.700nMpH: 7.5 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM28365(CHEMBL512355 | N-[4-(2-cyanoethyl)cyclohexyl]-N-cy...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of 11beta-HSD2 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen

LigandPNGBDBM28365(CHEMBL512355 | N-[4-(2-cyanoethyl)cyclohexyl]-N-cy...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in HEK293 cells in presence of 3% human serum albuminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen

LigandPNGBDBM28365(CHEMBL512355 | N-[4-(2-cyanoethyl)cyclohexyl]-N-cy...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of human cloned 11beta-HSD1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen

LigandPNGBDBM28365(CHEMBL512355 | N-[4-(2-cyanoethyl)cyclohexyl]-N-cy...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen

LigandPNGBDBM28365(CHEMBL512355 | N-[4-(2-cyanoethyl)cyclohexyl]-N-cy...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of 11beta-HSD1 in human adipocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed