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BDBM284942 US10023583, Example 14

SMILES: N[C@@H](CCC1CCC1)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O

InChI Key: InChIKey=MELWPQSYYFUIMX-RBBKRZOGSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 284942   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM284942
PNG
(US10023583, Example 14)
Show SMILES N[C@@H](CCC1CCC1)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1S/C22H30N2O4/c23-20(9-7-14-2-1-3-14)22(27,21(25)26)13-18-17-12-16(8-6-15-4-5-15)28-19(17)10-11-24-18/h10-12,14-15,20,27H,1-9,13,23H2,(H,25,26)/t20-,22+/m0/s1
PDB

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KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/a 3.90n/an/an/an/an/an/a



Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM284942
PNG
(US10023583, Example 14)
Show SMILES N[C@@H](CCC1CCC1)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1S/C22H30N2O4/c23-20(9-7-14-2-1-3-14)22(27,21(25)26)13-18-17-12-16(8-6-15-4-5-15)28-19(17)10-11-24-18/h10-12,14-15,20,27H,1-9,13,23H2,(H,25,26)/t20-,22+/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/a 0.800n/an/an/an/an/an/a



Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair