BDBM284980 4-(3-amino-5-fluorophenyl)-2- methylisoquinolin-1-one::US10023592, Example 25::US10941160, Example 25

SMILES Cn1cc(-c2cc(N)cc(F)c2)c2ccccc2c1=O

InChI Key InChIKey=HFXJXEJLKHMMSN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 284980   

TargetBromodomain-containing protein 4(Homo sapiens (Human))
Celgene Quanticel Research

US Patent
LigandPNGBDBM284980(4-(3-amino-5-fluorophenyl)-2- methylisoquinolin-1-...)
Affinity DataIC50:  2.75E+3nMAssay Description:Determination of the IC50 for the heterocyclic derivative BRD4 inhibitors disclosed herein was performed as follows. His-tagged BRD4 was cloned, expr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Celgene Quanticel Research

US Patent
LigandPNGBDBM284980(4-(3-amino-5-fluorophenyl)-2- methylisoquinolin-1-...)
Affinity DataIC50:  2.75E+3nMpH: 7.3Assay Description:Determination of the IC50 for the heterocyclic derivative BRD4 inhibitors disclosed herein was performed as follows. His-tagged BRD4 was cloned, expr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent