BDBM285098 4-[5-(cyclopropylmethoxy)-2- (methylsulfonylmethyl)pyrimidin-4-yl]-2- methylisoquinolin-1-one::US10023592, Example 143

SMILES Cn1cc(-c2nc(CS(C)(=O)=O)ncc2OCC2CC2)c2ccccc2c1=O

InChI Key InChIKey=YVEZTYYLJSOPFM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 285098   

TargetBromodomain-containing protein 4(Homo sapiens (Human))
Celgene Quanticel Research

US Patent
LigandPNGBDBM285098(4-[5-(cyclopropylmethoxy)-2- (methylsulfonylmethyl...)
Affinity DataIC50: <500nMpH: 7.3Assay Description:Determination of the IC50 for the heterocyclic derivative BRD4 inhibitors disclosed herein was performed as follows. His-tagged BRD4 was cloned, expr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent