BDBM285156 4-[3-(cyclopropylmethoxy)-6- methylsulfonylpyridin-2-yl]-7-fluoro-2- methylisoquinolin-1-one::BDBM486000::US10023592, Example 201

SMILES Cn1cc(-c2nc(ccc2OCC2CC2)S(C)(=O)=O)c2ccc(F)cc2c1=O

InChI Key InChIKey=JORWJXZWMRRVDZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 285156   

TargetBromodomain-containing protein 4(Homo sapiens (Human))
Celgene Quanticel Research

US Patent
LigandPNGBDBM285156(4-[3-(cyclopropylmethoxy)-6- methylsulfonylpyridin...)
Affinity DataIC50: <500nMAssay Description:Determination of the IC50 for the heterocyclic derivative BRD4 inhibitors disclosed herein was performed as follows. His-tagged BRD4 was cloned, expr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Celgene Quanticel Research

US Patent
LigandPNGBDBM285156(4-[3-(cyclopropylmethoxy)-6- methylsulfonylpyridin...)
Affinity DataIC50: <500nMpH: 7.3Assay Description:Determination of the IC50 for the heterocyclic derivative BRD4 inhibitors disclosed herein was performed as follows. His-tagged BRD4 was cloned, expr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent