BDBM285533 N-Cyclopropyl-3-([1,2,4]triazolo[1,5-a]pyridin-6-yl)imidazo[1,2-b]pyridazine-2-carboxamide (6)::US10077269, Example 6::US10669279, Example 6::US9598421, Example 6

SMILES O=C(NC1CC1)c1nc2cccnn2c1-c1ccc2ncnn2c1

InChI Key InChIKey=KZFDLYSKEWBCTB-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 285533   

TargetIsoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1)(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM285533(N-Cyclopropyl-3-([1,2,4]triazolo[1,5-a]pyridin-6-y...)
Affinity DataIC50:  64.4nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM285533(N-Cyclopropyl-3-([1,2,4]triazolo[1,5-a]pyridin-6-y...)
Affinity DataIC50:  49.3nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM285533(N-Cyclopropyl-3-([1,2,4]triazolo[1,5-a]pyridin-6-y...)
Affinity DataIC50:  326nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM285533(N-Cyclopropyl-3-([1,2,4]triazolo[1,5-a]pyridin-6-y...)
Affinity DataIC50:  4.89E+3nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM285533(N-Cyclopropyl-3-([1,2,4]triazolo[1,5-a]pyridin-6-y...)
Affinity DataIC50:  64.4nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM285533(N-Cyclopropyl-3-([1,2,4]triazolo[1,5-a]pyridin-6-y...)
Affinity DataIC50:  4.89E+3nMAssay Description:Human PDE4A3 coding sequence (amino acids 2 to 825 from the sequence with accession number NP_001104779) was cloned into the baculovirus expression v...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM285533(N-Cyclopropyl-3-([1,2,4]triazolo[1,5-a]pyridin-6-y...)
Affinity DataIC50:  326nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM285533(N-Cyclopropyl-3-([1,2,4]triazolo[1,5-a]pyridin-6-y...)
Affinity DataIC50:  4.89E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM285533(N-Cyclopropyl-3-([1,2,4]triazolo[1,5-a]pyridin-6-y...)
Affinity DataIC50:  64.4nMAssay Description:Human PDE4A3 coding sequence (amino acids 2 to 825 from the sequence with accession number NP_001104779) was cloned into the baculovirus expression v...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM285533(N-Cyclopropyl-3-([1,2,4]triazolo[1,5-a]pyridin-6-y...)
Affinity DataIC50:  49.3nMAssay Description:Human PDE4A3 coding sequence (amino acids 2 to 825 from the sequence with accession number NP_001104779) was cloned into the baculovirus expression v...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM285533(N-Cyclopropyl-3-([1,2,4]triazolo[1,5-a]pyridin-6-y...)
Affinity DataIC50:  326nMAssay Description:Human PDE4A3 coding sequence (amino acids 2 to 825 from the sequence with accession number NP_001104779) was cloned into the baculovirus expression v...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM285533(N-Cyclopropyl-3-([1,2,4]triazolo[1,5-a]pyridin-6-y...)
Affinity DataIC50:  49.3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent