BDBM285564 N-(bicyclo[1.1.1]pent-1-yl)-3-(4-chlorophenyl)imidazo[1,2-b]pyridazine-2-carboxamide::US10077269, Example 37::US10669279, Example 37::US9598421, Example 37

SMILES Clc1ccc(cc1)-c1c(nc2cccnn12)C(=O)NC12CC(C1)C2

InChI Key InChIKey=COONGBDOJFYLER-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 285564   

TargetIsoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1)(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM285564(N-(bicyclo[1.1.1]pent-1-yl)-3-(4-chlorophenyl)imid...)
Affinity DataIC50:  127nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM285564(N-(bicyclo[1.1.1]pent-1-yl)-3-(4-chlorophenyl)imid...)
Affinity DataIC50:  75.3nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM285564(N-(bicyclo[1.1.1]pent-1-yl)-3-(4-chlorophenyl)imid...)
Affinity DataIC50:  161nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM285564(N-(bicyclo[1.1.1]pent-1-yl)-3-(4-chlorophenyl)imid...)
Affinity DataIC50:  2.57E+3nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM285564(N-(bicyclo[1.1.1]pent-1-yl)-3-(4-chlorophenyl)imid...)
Affinity DataIC50:  127nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM285564(N-(bicyclo[1.1.1]pent-1-yl)-3-(4-chlorophenyl)imid...)
Affinity DataIC50:  2.57E+3nMAssay Description:Human PDE4A3 coding sequence (amino acids 2 to 825 from the sequence with accession number NP_001104779) was cloned into the baculovirus expression v...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM285564(N-(bicyclo[1.1.1]pent-1-yl)-3-(4-chlorophenyl)imid...)
Affinity DataIC50:  161nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM285564(N-(bicyclo[1.1.1]pent-1-yl)-3-(4-chlorophenyl)imid...)
Affinity DataIC50:  2.57E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM285564(N-(bicyclo[1.1.1]pent-1-yl)-3-(4-chlorophenyl)imid...)
Affinity DataIC50:  127nMAssay Description:Human PDE4A3 coding sequence (amino acids 2 to 825 from the sequence with accession number NP_001104779) was cloned into the baculovirus expression v...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM285564(N-(bicyclo[1.1.1]pent-1-yl)-3-(4-chlorophenyl)imid...)
Affinity DataIC50:  75.3nMAssay Description:Human PDE4A3 coding sequence (amino acids 2 to 825 from the sequence with accession number NP_001104779) was cloned into the baculovirus expression v...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM285564(N-(bicyclo[1.1.1]pent-1-yl)-3-(4-chlorophenyl)imid...)
Affinity DataIC50:  161nMAssay Description:Human PDE4A3 coding sequence (amino acids 2 to 825 from the sequence with accession number NP_001104779) was cloned into the baculovirus expression v...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM285564(N-(bicyclo[1.1.1]pent-1-yl)-3-(4-chlorophenyl)imid...)
Affinity DataIC50:  75.3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent