BDBM28568 N-({3-[12-methyl-8-(methylamino)-5-thia-3,7,10,12-tetraazatricyclo[7.3.0.0^{2,6}]dodeca-1(9),2(6),3,7,10-pentaen-4-yl]phenyl}methyl)acetamide::thiazole-based tricyclic inhibitor, 36a
SMILES CNc1nc2sc(nc2c2n(C)cnc12)-c1cccc(CNC(C)=O)c1
InChI Key InChIKey=JBRXERAIDOFGSA-UHFFFAOYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 28568
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb
Bristol-Myers Squibb
Affinity DataIC50: 22nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme catalyzed phosphorylation of GST-I-kappa-B-alpha were performed by adding enzyme at room temperature to substrate solutio...More data for this Ligand-Target Pair
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Bristol-Myers Squibb
Bristol-Myers Squibb
Affinity DataIC50: 1.90E+3nMT: 2°CAssay Description:Assays measuring the enzyme catalyzed phosphorylation of GST-I-kappa-B-alpha were performed by adding enzyme at room temperature to substrate solutio...More data for this Ligand-Target Pair
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb
Bristol-Myers Squibb
Affinity DataIC50: 22nMAssay Description:Inhibition of human IKKbeta using GST-IkappaBalpha as substrateMore data for this Ligand-Target Pair
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb
Bristol-Myers Squibb
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Bristol-Myers Squibb
Bristol-Myers Squibb
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of IKK1More data for this Ligand-Target Pair