BDBM286274 5-[(4-fluoro-1-methylpiperidin-4-yl)carbonyl]-N-(5-fluoro-2-methylpyrimidin-4-yl)-6,6-dimethyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-amine::US11220518, Ex. No. F1::US11780853, Example F1::US9518060, Example F1

SMILES CN1CCC(F)(CC1)C(=O)N1Cc2c(Nc3nc(C)ncc3F)n[nH]c2C1(C)C

InChI Key InChIKey=IQSHZZYSJWFHLL-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 286274   

TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM286274(5-[(4-fluoro-1-methylpiperidin-4-yl)carbonyl]-N-(5...)
Affinity DataKi:  39.9nMpH: 7.4Assay Description:Protein Kinase C beta 2 (PKCβII) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C beta type Isoform 2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM286274(5-[(4-fluoro-1-methylpiperidin-4-yl)carbonyl]-N-(5...)
Affinity DataKi:  39.9nMAssay Description:Protein Kinase C beta 2 (PKCpII) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate peptide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C beta type(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM286274(5-[(4-fluoro-1-methylpiperidin-4-yl)carbonyl]-N-(5...)
Affinity DataKi:  39.9nMAssay Description:A typical assay was carried out on a 96-well, clear microtiter plate in a Molecular Devices spectrophotometer for 20 minutes at 30° C. in 0.1 mL of a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent