BDBM286339 4-(6,8-difluoro-[1,2,4] triazolo[1,5-a]pyridin-2- yl)isoquinoline::US9567333, 18

SMILES Fc1cc(F)c2nc(nn2c1)-c1cncc2ccccc12

InChI Key InChIKey=KMTZQOIBRPIKLJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 286339   

TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM286339(4-(6,8-difluoro-[1,2,4] triazolo[1,5-a]pyridin-2- ...)
Affinity DataIC50: >8.33E+3nMAssay Description:CYP11B1 Assays: V79 cell lines stably expressing the either the human CYP11B2 or the human CYP11B1 enzyme were generated using a standard transfectio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM286339(4-(6,8-difluoro-[1,2,4] triazolo[1,5-a]pyridin-2- ...)
Affinity DataIC50:  126nMAssay Description:CYP11B1 Assays: V79 cell lines stably expressing the either the human CYP11B2 or the human CYP11B1 enzyme were generated using a standard transfectio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent