BDBM286585 US9566312, Compound 2.17.3

SMILES CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H]([C@@H](C)CN2CCN(CC2)C2CCC2)N(C)C(=O)[C@@H](C)N(C)C1=O)C(C)C

InChI Key InChIKey=CZZUTPHCSFXCCD-PBRDOJEVSA-N

Data  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 286585   

TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM286585(US9566312, Compound 2.17.3)
Affinity DataKd:  0.5nMpH: 7.4Assay Description:Binding of inhibitors to expressed cyclophilins was determined using surface plasmon resonance (SPR) experiments. Briefly, avi-tagged cyclophilin pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPeptidyl-prolyl cis-trans isomerase F, mitochondrial(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM286585(US9566312, Compound 2.17.3)
Affinity DataKd:  0.300nMpH: 7.4Assay Description:Binding of inhibitors to expressed cyclophilins was determined using surface plasmon resonance (SPR) experiments. Briefly, avi-tagged cyclophilin pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPeptidyl-prolyl cis-trans isomerase B(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM286585(US9566312, Compound 2.17.3)
Affinity DataKd:  0.400nMpH: 7.4Assay Description:Binding of inhibitors to expressed cyclophilins was determined using surface plasmon resonance (SPR) experiments. Briefly, avi-tagged cyclophilin pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent