BDBM287553 (R)-8-(2-((1-acryloylazetidin-3-yl)(methyl)amino)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one::US10294223, Cpd No. 125::US11078199, Cpd 125::US9567334, Example 125

SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(C[C@@H](C)N(C)C3CN(C3)C(=O)C=C)c2n1

InChI Key InChIKey=BOEATDPKXDSURV-CQSZACIVSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 287553   

TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma

US Patent
LigandPNGBDBM287553((R)-8-(2-((1-acryloylazetidin-3-yl)(methyl)amino)p...)
Affinity DataIC50:  1.10nMT: 2°CAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma

US Patent
LigandPNGBDBM287553((R)-8-(2-((1-acryloylazetidin-3-yl)(methyl)amino)p...)
Affinity DataIC50:  1.10nMAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma

US Patent
LigandPNGBDBM287553((R)-8-(2-((1-acryloylazetidin-3-yl)(methyl)amino)p...)
Affinity DataIC50:  1.10nMAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent