BDBM287617 US10085983, Compound J-12

SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc2ccc(-c3ccn(C)c3)n2n1

InChI Key InChIKey=VRTQWMWQYLZAOW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 287617   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM287617(US10085983, Compound J-12)
Affinity DataIC50:  8nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Homo sapiens (Human))
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM287617(US10085983, Compound J-12)
Affinity DataIC50:  1.90nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent