BDBM287823 6-(3,4-dihydro-2H- chromen-2-ylcarbonyl)-8- morpholin-4-yl-6,11- dihydro-5H-pyrido[2,3- b][1,5]benzodiazepine::US10086000, Example 41::US10508108, Example 41

SMILES O=C(C1CCc2ccccc2O1)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1

InChI Key InChIKey=YKXYFKWKXJMBAT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 287823   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM287823(6-(3,4-dihydro-2H- chromen-2-ylcarbonyl)-8- morpho...)
Affinity DataIC50:  95nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series. 125 nL of each dilution or DMSO alone is disp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM287823(6-(3,4-dihydro-2H- chromen-2-ylcarbonyl)-8- morpho...)
Affinity DataIC50:  95nMpH: 7.0 T: 2°CAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series. 125 nL of each dilution or DMSO alone is disp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent