BDBM287834 8-morpholin-4-yl-6- [(4aS,6S,8aR)-octahydro- 2H-chromen-6- ylcarbonyl]-6,11-dihydro- 5H-pyrido[2,3-b] [1,5]benzodiazepine::US10086000, Example 52::US10508108, Example 52

SMILES O=C([C@H]1CC[C@H]2OCCC[C@H]2C1)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1

InChI Key InChIKey=UTMOKHXHNIIZLQ-AXHZCLLHSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 287834   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM287834(8-morpholin-4-yl-6- [(4aS,6S,8aR)-octahydro- 2H-ch...)
Affinity DataIC50:  257nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series. 125 nL of each dilution or DMSO alone is disp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM287834(8-morpholin-4-yl-6- [(4aS,6S,8aR)-octahydro- 2H-ch...)
Affinity DataIC50:  257nMpH: 7.0 T: 2°CAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series. 125 nL of each dilution or DMSO alone is disp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent