BDBM287893 2-Ethoxy-11-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-ylcarbonyl)-10,11-dihydro-5H-dipyrido[2,3-b:2′,3′-e][1,4]diazepine::US10086000, Example 110::US10508108, Example 110

SMILES CCOc1ccc2Nc3ncccc3CN(C(=O)C3CCc4ccccc4CC3)c2n1

InChI Key InChIKey=FMQGKDVYSZFALS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 287893   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM287893(2-Ethoxy-11-(6,7,8,9-tetrahydro-5H-benzo[7]annulen...)
Affinity DataIC50:  18nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series. 125 nL of each dilution or DMSO alone is disp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM287893(2-Ethoxy-11-(6,7,8,9-tetrahydro-5H-benzo[7]annulen...)
Affinity DataIC50:  18nMpH: 7.0 T: 2°CAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series. 125 nL of each dilution or DMSO alone is disp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent