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BDBM28803 2-[4-(4-chlorophenoxy)phenoxy]propanoic acid::Clofop::Fenofibric acid::HCG 004

SMILES: CC(Oc1ccc(Oc2ccc(Cl)cc2)cc1)C(O)=O

InChI Key: InChIKey=BSFAVVHPEZCASB-UHFFFAOYSA-N

Data: 2 IC50  5 EC50

Find this compound or compounds like it in BindingDB or PDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 28803   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM28803
PNG
(2-[4-(4-chlorophenoxy)phenoxy]propanoic acid | Clo...)
Show SMILES CC(Oc1ccc(Oc2ccc(Cl)cc2)cc1)C(O)=O
Show InChI InChI=1S/C15H13ClO4/c1-10(15(17)18)19-12-6-8-14(9-7-12)20-13-4-2-11(16)3-5-13/h2-10H,1H3,(H,17,18)
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Article
PubMed
n/an/a>9.84E+4n/a 1.16E+4n/an/a8.022



Bristol-Myers Squibb Company



Assay Description
For hPPAR alpha, percentage inhibition was calculated relative to unlabeled GW2331, which was used as the active site-specific competitive binder. Fl...


J Pharmacol Exp Ther 327: 716-26 (2008)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM28803
PNG
(2-[4-(4-chlorophenoxy)phenoxy]propanoic acid | Clo...)
Show SMILES CC(Oc1ccc(Oc2ccc(Cl)cc2)cc1)C(O)=O
Show InChI InChI=1S/C15H13ClO4/c1-10(15(17)18)19-12-6-8-14(9-7-12)20-13-4-2-11(16)3-5-13/h2-10H,1H3,(H,17,18)
PDB
MMDB

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KEGG

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PC sid
UniChem

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Article
PubMed
n/an/a>9.84E+4n/a>5.00E+4n/an/a8.022



Bristol-Myers Squibb Company



Assay Description
For PPARgamma, the percentage inhibition was calculated relative to rosiglitazone, which was used as the active site-specific competitive binder. Flu...


J Pharmacol Exp Ther 327: 716-26 (2008)

More data for this
Ligand-Target Pair
Peroxisome Proliferator-Activated Receptor alpha


(Rattus norvegicus)
BDBM28803
PNG
(2-[4-(4-chlorophenoxy)phenoxy]propanoic acid | Clo...)
Show SMILES CC(Oc1ccc(Oc2ccc(Cl)cc2)cc1)C(O)=O
Show InChI InChI=1S/C15H13ClO4/c1-10(15(17)18)19-12-6-8-14(9-7-12)20-13-4-2-11(16)3-5-13/h2-10H,1H3,(H,17,18)
PDB
MMDB

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Article
PubMed
n/an/an/an/a 1.77E+4n/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
EC50 is the concentration of test compounds needed to induce 50% of the maximum luciferase activity in HEK cells transfected with PPAR and Gal4-lucif...


J Pharmacol Exp Ther 327: 716-26 (2008)

More data for this
Ligand-Target Pair
Peroxisome Proliferator-Activated Receptor alpha


(Mus musculus)
BDBM28803
PNG
(2-[4-(4-chlorophenoxy)phenoxy]propanoic acid | Clo...)
Show SMILES CC(Oc1ccc(Oc2ccc(Cl)cc2)cc1)C(O)=O
Show InChI InChI=1S/C15H13ClO4/c1-10(15(17)18)19-12-6-8-14(9-7-12)20-13-4-2-11(16)3-5-13/h2-10H,1H3,(H,17,18)
PDB
MMDB

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KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Patents


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Article
PubMed
n/an/an/an/a 1.85E+4n/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
EC50 is the concentration of test compounds needed to induce 50% of the maximum luciferase activity in HEK cells transfected with PPAR and Gal4-lucif...


J Pharmacol Exp Ther 327: 716-26 (2008)

More data for this
Ligand-Target Pair
Peroxisome Proliferator-Activated Receptor alpha


(Mesocricetus auratus (golden hamster))
BDBM28803
PNG
(2-[4-(4-chlorophenoxy)phenoxy]propanoic acid | Clo...)
Show SMILES CC(Oc1ccc(Oc2ccc(Cl)cc2)cc1)C(O)=O
Show InChI InChI=1S/C15H13ClO4/c1-10(15(17)18)19-12-6-8-14(9-7-12)20-13-4-2-11(16)3-5-13/h2-10H,1H3,(H,17,18)
PDB
MMDB

UniProtKB/TrEMBL

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PC cid
PC sid
UniChem

Patents


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Article
PubMed
n/an/an/an/a 2.87E+4n/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
EC50 is the concentration of test compounds needed to induce 50% of the maximum luciferase activity in HEK cells transfected with PPAR and Gal4-lucif...


J Pharmacol Exp Ther 327: 716-26 (2008)

More data for this
Ligand-Target Pair