BDBM288215 2-Cyclopropyl-8-fluoro-5-(7-methyl-1H-indazol-5-yl)-6-::US10087185, Example 33

SMILES Cc1cc(cc2cn[nH]c12)-c1c(cc(F)c2nc(nn12)C1CC1)C(F)(F)F

InChI Key InChIKey=CWOVUBDHGYEAQX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 288215   

TargetVoltage-dependent calcium channel gamma-8 subunit(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288215(2-Cyclopropyl-8-fluoro-5-(7-methyl-1H-indazol-5-yl...)
Affinity DataIC50:  0.200nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent