BDBM288271 5-(7-Chloro-1H-indazol-5-yl)-2,8-diethyl-6-(trifluoromethyl)-::US10087185, Example 89

SMILES CCc1nc2c(CC)cc(c(-c3cc(Cl)c4[nH]ncc4c3)n2n1)C(F)(F)F

InChI Key InChIKey=YBHPBHDLEXUXCN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 288271   

TargetVoltage-dependent calcium channel gamma-8 subunit(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288271(5-(7-Chloro-1H-indazol-5-yl)-2,8-diethyl-6-(triflu...)
Affinity DataIC50:  0.794nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent