BDBM288439 (1S,3R)-3-[8-amino-1- (4-{[4- (trifluoromethyl) pyridin-2- yl]carbamoyl}phenyl) imidazo[1,5-a]pyrazin- 3-yl]-1-(1- methylethyl) cyclopentane carboxylic acid::US10087188, Example 46
SMILES CC(C)[C@@]1(CC[C@H](C1)c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12)C(O)=O
InChI Key InChIKey=BBBNOGAOTKAXSX-CLYVBNDRSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 288439
Affinity DataIC50: 0.960nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Inhibition of BTK in human PBMCMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of 6-His-tagged recombinant full length BTK (unknown origin) expressed in baculovirus-transfected Sf9 cells using Biotin-EQEDEPEGDYFEWLE-N...More data for this Ligand-Target Pair