BDBM288459 4-[8-amino-1-(2- ethoxy-4-{[4- (trifluoromethyl) pyridin-2- yl]carbamoyl}phenyl) imidazo[1,5-a]pyrazin- 3-yl]-2,2,5,5- tetrafluorobicyclo [2.2.2]octane-1-carboxylic acid::US10087188, Example 66

SMILES CCOc1cc(ccc1-c1nc(n2ccnc(N)c12)C12CCC(CC1(F)F)(C(O)=O)C(F)(F)C2)C(=O)Nc1cc(ccn1)C(F)(F)F

InChI Key InChIKey=UMQCYTMJOHLBCY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 288459   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM288459(4-[8-amino-1-(2- ethoxy-4-{[4- (trifluoromethyl) p...)
Affinity DataIC50:  0.470nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent