BDBM288675 (E)-3-(3,5-difluoro-4-((6S,8R/6R,8S)-(7-isobutyl-8-methyl-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl)phenyl)acrylic acid::US10087191, Example 92

SMILES CC(C)CN1C(C)Cc2c(ccc3[nH]ncc23)C1c1c(F)cc(\C=C\C(O)=O)cc1F

InChI Key

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 288675   

TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM288675((E)-3-(3,5-difluoro-4-((6S,8R/6R,8S)-(7-isobutyl-8...)
Affinity DataIC50:  0.430nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent